Polyamine Transport by Mammalian Cells and Mitochondria
نویسندگان
چکیده
منابع مشابه
Polyamine transport by mammalian cells and mitochondria: role of antizyme and glycosaminoglycans.
The role of antizyme (AZ) and glycosaminoglycans in polyamine uptake by mammalian cells and mitochondria was examined using NIH3T3 and FM3A cells and rat liver mitochondria. AZ is synthesized as two isoforms (29 and 24.5 kDa) due to the existence of two initiation codon AUGs in the AZ mRNA. Most AZ existed as the 24.5-kDa form translatable from the second AUG, but a portion of the 29-kDa AZ fro...
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Agmatine is a biogenic amine with the capacity to regulate a number of nonreceptor-mediated functions in mammalian cells, including intracellular polyamine content and nitric oxide generation. We observed avid incorporation of agmatine into several mammalian cell lines and herein characterize agmatine transport in mammalian cells. In transformed NIH/3T3 cells, agmatine uptake is energy dependen...
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Introduction The cell concentration of a polyamine depends on both its rates of synthesis and degradation and on its rates of uptake and release. A system for the uptake of putrescine, spermidine and spermine is possessed by many types of cell [ 1 1 , and the uptake of a particular polyamine is often stimulated when its synthesis is inhibited [2]. The transport system is thus involved in the re...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m505445200